Composition
Each 1 ml contains:
- Sulfadiazine sodium: 100 mg
- Trimethoprim: 20 mg
Pharmaceutical Form
Sterile solution for injection.
Pharmacological Properties
Dadprim Solution Injection combines sulfadiazine and trimethoprim, resulting in a synergistic bactericidal effect. The dual action of the two components inhibits sequential steps in bacterial folic acid synthesis, making the combination highly effective against a wide range of Gram-positive and Gram-negative bacteria.
It is particularly useful for treating infections caused by multi-resistant bacteria, including Escherichia coli, Streptococcus, Proteus, Salmonella, Pasteurella, Shigella, Haemophilus, Staphylococcus, Neisseria, Klebsiella, Fusiformis, Corynebacterium, Clostridium, and Bordetella.
Target Species
Cattle, sheep, goats, horses, dogs, and cats.
Indications for Use
Dadprim Solution Injection is indicated for the treatment of acute, subacute, and chronic bacterial infections in both large and small animals. It is effective against:
- Respiratory tract infections
- Gastrointestinal infections
- Urogenital tract infections
- Mastitis, foot infections, and other soft tissue infections
- Infections of the eye, ear, and mouth
It is especially valuable when rapid, broad-spectrum antibacterial action is required.
Contraindications and Precautions
- Do not use in animals with known sulfonamide hypersensitivity.
- Contraindicated in animals with hepatic or renal impairment.
- Do not administer to horses with drug-induced arrhythmias.
- Ensure animals have access to adequate drinking water during treatment.
- Use aseptic technique during injection.
- For IV use, warm the solution to body temperature and inject slowly.
- Discontinue treatment immediately if any signs of intolerance appear.
- Individuals with sulfonamide sensitivity should avoid handling this product.
Undesirable Effects
- Adverse effects are rare at recommended doses.
- No significant side effects have been reported under normal usage conditions.
Posology and Method of Administration
Administer intramuscularly or slowly intravenously as follows:
- Cattle, sheep, goats: 2 ml per 16 kg body weight once daily
- Horses: 2 ml per 16 kg body weight by slow IV injection
- Dogs and cats: 2 ml per 8 kg body weight by subcutaneous injection only
In mild cases, a single injection may be sufficient. In more severe cases, treatment may be repeated daily for up to 5 days, or 2 days after symptoms disappear.
Overdose
No adverse effects have been reported at therapeutic doses.
Withdrawal Period
- Milk: 48 hours
- Meat: 12 days
Do not use animal products for human consumption during treatment.
Special Safety Precautions for the Person Administering the Product
No special precautions are required under standard handling conditions.
Special Precautions for Storage
Store in a dry place below 30°C.
Protect from light.
Do not refrigerate.
Nature and Contents of Container
Clear, colorless to pale yellow solution in amber glass vials – 100 ml.
For veterinary use only. Consult a veterinarian before use.
