Composition

Each 1 ml contains:

• Hydrochlorothiazide: 50 mg
• Dexamethasone: 0.5 mg

Pharmaceutical Form

Sterile injectable solution
Appearance: colorless to pale yellow solution

Pharmacological Properties

Diuredex Injection combines the anti-inflammatory and anti-edematous properties of dexamethasone with the diuretic effect of hydrochlorothiazide.

• Dexamethasone reduces inflammation in connective tissue, helping relieve edema caused by allergic or inflammatory conditions.
• Hydrochlorothiazide promotes diuresis by enhancing renal excretion of water and electrolytes, reducing fluid accumulation.

The synergistic action of both ingredients makes Diuredex® an effective option in managing localized and systemic edema.

Target Species

Horses, foals, cattle, calves

Indications for Use

Horses and foals:

• Generalized congestion and edema
• Sheath edema
• Anasarca
• Edema associated with allergic reactions

Cattle and calves:

• Udder congestion and edema
• Persistent postpartum udder edema
• Pulmonary congestion and edema
• Edema around surgical wounds
• Allergic edema

Contraindications

Do not use in animals that are:

• Pregnant
• Diabetic
• Suffering from viral infections during the viremic phase
• Diagnosed with congestive heart failure, chronic nephritis, hepatic encephalopathy, osteoporosis, glaucoma, or severe hypokalemia
• Hypersensitive to any of the active ingredients
• Horses suffering from laminitis

Undesirable Effects

No adverse effects are expected at recommended dosages.

Posology and Method of Administration

For intramuscular or slow intravenous use. Dosage should be adjusted by a veterinarian depending on the severity of the condition.

Adult horses and cattle:

• Preventive treatment: 10 ml daily for 3 days
• Mild edema/congestion: 10 ml daily for 2–3 days
• Severe edema/congestion: 20 ml daily for 2 days, then 10 ml on the third day

Foals and calves:

• 2 ml per 40–50 kg body weight daily for 3 days

Overdose

No specific adverse effects reported with overdose under field conditions.

Withdrawal Periods

• Meat and offal: 28 days
• Milk: 7 days
• Horses: Treated animals must not be slaughtered for human consumption

Special Safety Precautions for the Person Administering the Product

No special precautions are required under normal use.

Special Precautions for Storage

• Store in a dry place below 30°C
• Do not refrigerate
• Protect from light

Packaging

Available in amber glass vials of 50 ml and 100 ml

For veterinary use only. Consult a veterinarian before use.