Composition

Each 7.87 g contains:

• Diminazene aceturate: 3.5 g
• Phenazone (Antipyrine): 4.36 g

Pharmaceutical Form

Sterile granules for reconstitution and injection

Pharmacological Properties

Trypanodad is a chemotherapeutic formulation combining diminazene aceturate and phenazone, designed for the treatment of Trypanosomiasis and Piroplasmosis.
Diminazene is a diamidine compound that acts by interfering with the DNA synthesis of blood-borne protozoan parasites. Phenazone provides anti-inflammatory and antipyretic effects, enhancing therapeutic efficacy and improving animal comfort during infection.

Target Species

Cattle, horses, and sheep

Indications for Use

Trypanodad is indicated for the treatment of:

• Trypanosomiasis caused by:
  Trypanosoma congolense, Trypanosoma vivax, Trypanosoma brucei
• Piroplasmosis caused by:
  Babesia bovis, Babesia bigemina, Babesia ovis, Babesia motasi, Babesia canis, and other blood parasites
• Mixed infections involving Trypanosomes and Piroplasmas
• Resistant strains of parasites that do not respond to standard treatments

Trypanodad ensures a complete cure in cases of Trypanosoma congolense and T. vivax infections.

Contraindications

• Do not administer to animals with known hepatic or renal impairment
• Contraindicated in animals with hypersensitivity to diminazene or phenazone

Undesirable Effects

• Rare at recommended doses
• High doses may cause mild local reactions

Special Precautions for Use

• Dissolve the 7.87 g sachet in 42 ml of sterile water for injection to obtain a 7% solution
• If kept at room temperature, the solution remains stable for 5 days
• If stored in a cool, dark place, it remains stable for 14 days
• Administer by deep intramuscular injection in the neck or thigh muscles
• For doses exceeding 10 ml, divide into two separate injection sites to reduce local pain

Posology and Method of Administration

Deep intramuscular injection only

• Standard dose: 3.5 mg/kg body weight (equivalent to 1 ml per 20 kg)
• For infections caused by Trypanosoma brucei: 7 mg/kg body weight
• In resistant infections, dosage may be increased to 8 mg/kg

Dosage reference table:

Overdose

Overdose may result in central nervous system toxicity, including symptoms such as ataxia and convulsions.

Withdrawal Period

• Meat: 28 days
• Milk: 10 days

Special Safety Precautions for the Person Administering the Product

• No specific hazards when handled as directed
• Always follow standard hygiene and injection protocols

Special Precautions for Storage

• Store in a dry place below 30°C
• Protect from light
• Reconstituted solution should be used within the stability period

Package

Each unit contains 7.87 g of granules to be dissolved in 42 ml of sterile water to produce 50 ml of injectable solution, supplied in glass vials with outer carton packaging

For veterinary use only. Consult a veterinarian before use.